1 00:00:00,420 --> 00:00:10,200 I think it's sort of like. 2 00:00:10,200 --> 00:00:15,270 I'm delighted to introduce Richard when he loves hit Hitler has been. 3 00:00:15,270 --> 00:00:20,940 So how pronunciation is right? Richard is an upper GI surgeon. 4 00:00:20,940 --> 00:00:33,060 He qualified from Rotterdam in the Netherlands and then he he did a Ph.D., which was awarded with honour. 5 00:00:33,060 --> 00:00:36,750 And he was a resident in Rotterdam. 6 00:00:36,750 --> 00:00:47,520 There's a lot of his surgical training, and then he was a fellow in surgical oncology in Amsterdam, the academic medical centre. 7 00:00:47,520 --> 00:00:53,010 Then he was appointed surgeon at the University Medical Centre in. 8 00:00:53,010 --> 00:01:11,490 And has been a full professor of GI oncology and programme group leader in 2009 and in 2015, he became head of surgical oncology in Italy. 9 00:01:11,490 --> 00:01:18,570 He has a very exciting programme, mainly focussed on minimally invasive interventions and robotic surgery. 10 00:01:18,570 --> 00:01:23,730 As you know, we have an expanding programme here in Oxford, which we've had for 10 years, 11 00:01:23,730 --> 00:01:28,710 and it's infiltrating all specialities, which I'm delighted about. 12 00:01:28,710 --> 00:01:31,890 He's also got the just speaking to him very briefly now. 13 00:01:31,890 --> 00:01:38,250 He's got an exciting programme on surgical imaging and also doing genetic profiling. 14 00:01:38,250 --> 00:01:46,170 He's authored a small number of 308 articles and 10 chapters. 15 00:01:46,170 --> 00:01:48,300 He's got many esteem indicators. 16 00:01:48,300 --> 00:01:56,250 He's president of many associations, community members, etc. And I won't take more time, which is we are delighted to have you. 17 00:01:56,250 --> 00:02:01,770 Thank you very much for sharing your experience with us. Thank you very much. 18 00:02:01,770 --> 00:02:08,940 Thank you very much for this very kind introduction and the invitation of Nick Maynard's and his team has Box, 19 00:02:08,940 --> 00:02:20,070 who is a fellow with us, and I think the Oxford Dutch Connexion is is is getting stronger and is getting better as he looks here. 20 00:02:20,070 --> 00:02:23,580 And then also some other colleagues from the Netherlands, 21 00:02:23,580 --> 00:02:31,840 and we talked yesterday about getting a joint meeting maybe next year or the day after which the Jewish versions of the Netherlands and the UK. 22 00:02:31,840 --> 00:02:36,450 And I think it would be fantastic. So looking forward to that. 23 00:02:36,450 --> 00:02:41,940 What I like to show you is our experience in them with robotic is a project to me over the years, 24 00:02:41,940 --> 00:02:52,530 and I'll show you also some some historical pictures of our our first project to meet with the robot. 25 00:02:52,530 --> 00:03:00,540 And if you look at the meta analysis, the reviews on this topic of many movies visual object to me. 26 00:03:00,540 --> 00:03:09,000 Actually, these are the items that always pop up and that the beneficial parts of a minimum of Asia for objectively are less blood loss, 27 00:03:09,000 --> 00:03:16,170 less complications, less pain and a faster recovery, actually, as we know also from for a coral rectal surgery. 28 00:03:16,170 --> 00:03:22,800 And the same counts for many, many years of physiologic to me. And I think this is really a landmark paper by Jim. 29 00:03:22,800 --> 00:03:29,370 Look at Age, who is in Pittsburgh and already in 2003, reported on 222 patients. 30 00:03:29,370 --> 00:03:32,460 Really impressive. He is one of the pioneers of this technique. 31 00:03:32,460 --> 00:03:44,850 I visited him in 2003 and I saw his technique and I thought that we could convert this technique into a robotic technique at that time. 32 00:03:44,850 --> 00:03:54,060 And this is actually the major landmark paper showing a randomised controlled trial of open versus minimum age is of Jack. 33 00:03:54,060 --> 00:03:57,000 To me, it's from the group, from Amsterdam, from Hugo Questar, 34 00:03:57,000 --> 00:04:06,120 showing especially less bone marrow complications and also less pain after one year follow up, 35 00:04:06,120 --> 00:04:12,480 meaning that the thoracotomy syndrome, which is causing pain, is still up to one year, 36 00:04:12,480 --> 00:04:18,240 resulting in a better quality of life after minimally invasive these objects. 37 00:04:18,240 --> 00:04:25,080 But still, this technique and this is a positive publication 2012 look at its 2003. 38 00:04:25,080 --> 00:04:28,320 This technique is not widely adopted. 39 00:04:28,320 --> 00:04:38,160 In 2007 and 2014, we did a survey amongst surgeons of the international societies for his office use through the Ujo and I as the EA. 40 00:04:38,160 --> 00:04:50,070 And here you see the distribution amongst the continents. About 250 222 surgeons were questions about a preference of surgical approach. 41 00:04:50,070 --> 00:04:59,700 And you see, in 2007, the minimally invasive technique is about 10 percent of all cases, and that increased to 40 percent in 2014. 42 00:04:59,700 --> 00:05:04,620 But the open technique still still nowadays, I think, is the standard of care. 43 00:05:04,620 --> 00:05:10,310 And maybe this this percentage has now increased that we are planning to do another survey next year. 44 00:05:10,310 --> 00:05:14,120 And but I think it will not be much higher than 50 percent, 45 00:05:14,120 --> 00:05:22,490 so what is the reason that this technique or those shown beneficial in is still not very widely adopted? 46 00:05:22,490 --> 00:05:30,380 I think it is overdue. Your surgery is really one of the most complex type of surgery involving the chest involving 47 00:05:30,380 --> 00:05:38,750 the moving organs in the chest with a very narrow band of of the section that you have. 48 00:05:38,750 --> 00:05:45,380 At the same time, you have to do a radical resection and with the minimum invasive surgery, have the two dimensional view. 49 00:05:45,380 --> 00:05:50,960 You had disturbed our hand coordination loss of dexterity because of the rigid instruments, 50 00:05:50,960 --> 00:05:55,130 and you are dependent on the assistance for the camera of you. 51 00:05:55,130 --> 00:05:57,890 And that is where I think robotic surgery comes in, 52 00:05:57,890 --> 00:06:04,820 showing you a three dimensional view 10 times and large should really looking very closely to the tissues. 53 00:06:04,820 --> 00:06:15,860 Looking through the plains very nicely, the natural eye and access is restored so you don't stand in an awkward position for your back, 54 00:06:15,860 --> 00:06:20,150 for example, high degrees of freedom because of the risks of the instruments. 55 00:06:20,150 --> 00:06:28,860 Actually, all the all the, uh, everything you can do was a pulse and more can be done with this instrument instrument. 56 00:06:28,860 --> 00:06:36,500 And I think this is the reason that for complex procedures such as is object to me, this is an excellent tool. 57 00:06:36,500 --> 00:06:41,930 We were very lucky to have one of the first robotic systems worldwide in 2002. 58 00:06:41,930 --> 00:06:50,150 We had the first standard system of DA Vinci in our hospital, which is a university hospital in Utrecht. 59 00:06:50,150 --> 00:06:54,290 And this is the device we had on the lab. So we had actually two systems. 60 00:06:54,290 --> 00:06:57,950 One was in the clinic. One was in the lab so we could develop new procedures. 61 00:06:57,950 --> 00:07:03,260 And we really at that time had no idea what procedures could be done robotically. 62 00:07:03,260 --> 00:07:10,820 So we started with easy procedures such as cholecystectomy and just looking for 63 00:07:10,820 --> 00:07:16,400 the optimal port position at that time because this is the standard system we had. 64 00:07:16,400 --> 00:07:25,370 You see, it is very bulky if you know the robots at this stage, the development after 20 years is much, much, much more elegant. 65 00:07:25,370 --> 00:07:30,140 But the basic principles of this system were already there. 66 00:07:30,140 --> 00:07:37,520 But you had to be very cautious in your positioning to be able not to get collision. 67 00:07:37,520 --> 00:07:40,910 The consul was here where the surgeon is operating, and that has changed as well. 68 00:07:40,910 --> 00:07:46,460 But the principles are still there and we developed this poor positioning for the thorax, 69 00:07:46,460 --> 00:07:53,750 meaning that you have the camera in the sixth intercostal space and to the robotic arms 70 00:07:53,750 --> 00:07:59,210 in the fourth and in the the cost of space and two to assisting ports at that time. 71 00:07:59,210 --> 00:08:01,730 The patient is in prone position, 72 00:08:01,730 --> 00:08:12,560 semi prone position to keep the lung out of the operative field so that you can approach the oesophagus from this side of the rights to direction, 73 00:08:12,560 --> 00:08:17,810 and the robot was typically put in the dorsal cranial position. 74 00:08:17,810 --> 00:08:23,090 And this is actually still the position we use with the sort essi robots. 75 00:08:23,090 --> 00:08:28,760 And this way you have an optimal vision and you have an approach from the diaphragm 76 00:08:28,760 --> 00:08:33,950 upper to the thoracic in that this really works very well with X iRobot's. 77 00:08:33,950 --> 00:08:40,670 This position is also automatically put into place by the the robotic arms, 78 00:08:40,670 --> 00:08:47,120 but this took us some time to get a four lap tube to find out which was the best position. 79 00:08:47,120 --> 00:08:50,360 And then I will show you some papers we produced over the years, 80 00:08:50,360 --> 00:08:58,940 starting with our early experience in 2003 to 2005 and looking to the description of the technique. 81 00:08:58,940 --> 00:09:05,330 And it was published in 2006, and actually that was the proof of concept of this technique. 82 00:09:05,330 --> 00:09:12,890 Then the the follow up paper was in British Journal of Surgery 47 patient describes showing 83 00:09:12,890 --> 00:09:21,110 also the quality of this procedure with a short term safety and some early modifications. 84 00:09:21,110 --> 00:09:29,720 And then between 2007 and 2011, we showed that also in a record of 100 patients, hundred and eight patients, 85 00:09:29,720 --> 00:09:36,080 the oncological outcome was at least comparable to what we know from open surgery. 86 00:09:36,080 --> 00:09:44,360 This is the survival curve in those patients, and we operated on there was a 300 patients in surgical oncology. 87 00:09:44,360 --> 00:09:48,200 And you see that the majority of our cases is advanced. 88 00:09:48,200 --> 00:09:57,920 Cancer is T three T for tumours of about 77 percent, and the majority also has a node positive disease at presentation. 89 00:09:57,920 --> 00:10:09,390 Nowadays, we usually give neoadjuvant therapy, but in this series, because it was included with our early experience, it was about 70 percent that. 90 00:10:09,390 --> 00:10:17,910 You achieve in therapy from 2006 on as your standard treatment before we did surgery only and with the median follow up of fifty seven months, 91 00:10:17,910 --> 00:10:27,540 the survival is five year survival is about 50 percent. So that is at least as good as we found in an open surgery. 92 00:10:27,540 --> 00:10:36,020 Then one of the very important things in the programme that we developed from 2003 on was the introduction of API. 93 00:10:36,020 --> 00:10:41,370 EPA is a physician assistant. We have that system in the Netherlands introduced it. 94 00:10:41,370 --> 00:10:55,380 So around that time, which is actually a nurse who is very educated in the certain area and we were very lucky to have Sylvia from the horses. 95 00:10:55,380 --> 00:11:02,340 She was a biologist at that time and also trained as a script nurse, and we trained her, especially for robotic surgery. 96 00:11:02,340 --> 00:11:08,670 And the reason for that was that we we had a resident at a stable situation before, 97 00:11:08,670 --> 00:11:18,840 and every time the resident went for his next steps, he went away and the programme went down and we had to train the rest. 98 00:11:18,840 --> 00:11:24,480 It was the chief resident and he was there was most of the time, a good surgeon. 99 00:11:24,480 --> 00:11:35,010 But the programme was not flying because you had you had this dip all the time when a new resident come in and this this changed 100 00:11:35,010 --> 00:11:44,280 really this this point with continuity of troubleshooting of a specialised nurse that knows everything about the instruments, 101 00:11:44,280 --> 00:11:52,050 the board positioning and the assistance. So from that on, we really could, could improve and could build up. 102 00:11:52,050 --> 00:11:55,560 And I think another important step for us was the standard system, 103 00:11:55,560 --> 00:12:08,240 which you had until 2009 was changed by the by the next generation to see system, and there was an important step as well. 104 00:12:08,240 --> 00:12:18,620 And another important step for our programme was the and the staff member also dedicated to robotic is obviously what surgery was usually Huda, 105 00:12:18,620 --> 00:12:21,920 who is now with us since 2011. 106 00:12:21,920 --> 00:12:31,070 And I think when you have a PR physician assistant and you build up your team with another staff member fully dedicated to this procedure, 107 00:12:31,070 --> 00:12:38,750 that is really possible to to make the next steps. And we looked into our learning curve at that time. 108 00:12:38,750 --> 00:12:45,500 The learning curve of myself and we compare that to the learning curve of the new colleague Yellow. 109 00:12:45,500 --> 00:12:56,210 And so we looked into the area of 2003 to 2016, and the initial case was of three hundred and twelve patients and the proctor, 110 00:12:56,210 --> 00:13:00,170 the two hundred and thirty two cases and the north is 80 cases. 111 00:13:00,170 --> 00:13:10,640 And we looked into that. Um, the data with the Q some methods, which means that you calculate for each item, 112 00:13:10,640 --> 00:13:15,560 you calculate the mean of the whole group and you can have that as a as a reference. 113 00:13:15,560 --> 00:13:22,730 And for each sample that you measure, you will measure the difference of the sound of the of that sample with the mean that you 114 00:13:22,730 --> 00:13:28,580 just calculated and then you have three options even and the sample is above average, 115 00:13:28,580 --> 00:13:32,450 which means that you are not not improving. 116 00:13:32,450 --> 00:13:36,680 Actually, it's at the level then the same as the average. 117 00:13:36,680 --> 00:13:44,570 Then you are a horizontal or you go below the average and then you are actually improving with your with your learning curve. 118 00:13:44,570 --> 00:13:50,000 And we looked into two items the operative time and we are looking to blood loss. 119 00:13:50,000 --> 00:13:56,030 And this is my curve starting in 2003. And you see that in 2008, 120 00:13:56,030 --> 00:14:05,960 the learning curve is is actually completed because you have a flattening of this line and you see that even after 130 cases, 121 00:14:05,960 --> 00:14:13,220 the line goes down, meaning that I'm improving actually all the time compared to the average, which was set at zero. 122 00:14:13,220 --> 00:14:19,280 Then you see, in 2013, we were expanding our experience with more difficult cases. 123 00:14:19,280 --> 00:14:23,270 So we're adding in, for example, T for B cases that we're down staged. 124 00:14:23,270 --> 00:14:27,200 And then you see the the line comes up again for operative time. 125 00:14:27,200 --> 00:14:32,630 But this is a very good measure. Looking at your, uh, you are experiencing a learning curve. 126 00:14:32,630 --> 00:14:39,740 And then the the novice surgeon, he was introduced by a structured training programme, 127 00:14:39,740 --> 00:14:46,460 meaning that he was first doing the table surgery, looking at about 20 cases. 128 00:14:46,460 --> 00:14:56,690 Learning actually all the steps of the procedure. Then he was introduced into the console, with the console surgeon beside him for about 15 cases, 129 00:14:56,690 --> 00:15:02,210 and after that, he was on his own, independently doing the procedures. 130 00:15:02,210 --> 00:15:08,330 After about 15 cases, you see, that was happening within one year in 2012. 131 00:15:08,330 --> 00:15:15,050 And then you see that only after about twenty two cases, including the proctoring phase, 132 00:15:15,050 --> 00:15:20,690 he has completed his learning curve and the line was flattening off and even going under the mean. 133 00:15:20,690 --> 00:15:25,760 And we also looked at all the oncological parameters during his training and all the 134 00:15:25,760 --> 00:15:31,700 oncological like lymph node dissection number and also like radical was just crazy. 135 00:15:31,700 --> 00:15:35,180 They were all at the level of the of the Proctor's surgeons. 136 00:15:35,180 --> 00:15:42,770 So without compromising the the quality of surgery, you can introduce this technique. 137 00:15:42,770 --> 00:15:50,750 And if you and then sum up what we did for this trainee, you see that the doctor completed his learning curve in seventy procedures. 138 00:15:50,750 --> 00:16:00,260 It was five years was the pioneering series and with a structured programme, you can reduce this time by twenty four procedures within one year. 139 00:16:00,260 --> 00:16:09,960 So that is a way we would like to continue for this, for training this and this technique. 140 00:16:09,960 --> 00:16:18,570 So the conclusion from our experience in this stage 2003 to 2012 was that as feasible as technically safe and logically 141 00:16:18,570 --> 00:16:26,190 safe and that you that we completed in this time the learning curve and also for the for the training programme. 142 00:16:26,190 --> 00:16:32,490 So at that time, it was 2012. We and we decided that we could do this technique. 143 00:16:32,490 --> 00:16:40,380 We could analyse the technique in a randomised controlled trial. There were no other centres worldwide that passed the learning curve at that point. 144 00:16:40,380 --> 00:16:47,460 So we decided actually it would be nice to do multi-center trial where we couldn't do that and decided to do a single centre, 145 00:16:47,460 --> 00:16:56,680 randomised controlled trial. Looking to this technique versus the open standard of transfer risk is over joke to me. 146 00:16:56,680 --> 00:17:04,180 But was the protocol was published in trials in 2012 and these were the items we are looking at. 147 00:17:04,180 --> 00:17:08,250 The study was running between 2012 and 2016. 148 00:17:08,250 --> 00:17:17,370 I think the nice thing of a randomised controlled trial that you really can prospectively analyse all the data very, very precisely. 149 00:17:17,370 --> 00:17:22,210 So to all the postoperative complications every week were discussed in a panel and 150 00:17:22,210 --> 00:17:27,390 this court's been scorched prospectively quality of life oncological outcomes. 151 00:17:27,390 --> 00:17:32,340 And we also looked even at cost because we know cost is with robotic surgery. 152 00:17:32,340 --> 00:17:40,530 Always an item. This is the this trial was this year published in the Annals of Surgery, 153 00:17:40,530 --> 00:17:49,770 and I will show you the results of the trial that we in total randomised one hundred and twelve patients looking into these two groups, 154 00:17:49,770 --> 00:17:58,030 and we ended up with fifty five versus fifty four. And this is the baseline characteristics just to show you type of surgery. 155 00:17:58,030 --> 00:18:03,030 It's the type of patients is typically male patients. 156 00:18:03,030 --> 00:18:11,010 The majority of 65 64 of age, there were no significant differences in all the baseline characteristics. 157 00:18:11,010 --> 00:18:16,260 The majority is out of the question normal about seventy eight seventy six percent. 158 00:18:16,260 --> 00:18:21,840 And a majority is also in the lower part of the oesophagus, the lower third of the oesophagus. 159 00:18:21,840 --> 00:18:29,690 As you can see here, about 80 percent received new HIV treatment. 160 00:18:29,690 --> 00:18:33,800 Are the baseline characteristics concerning comorbidity and medical history, 161 00:18:33,800 --> 00:18:40,370 you see that the majority had a comorbidity 75 to 80 percent has comorbidity and 162 00:18:40,370 --> 00:18:50,670 the majority of that is cardiac and vascular and also pulmonary comorbidity. 163 00:18:50,670 --> 00:18:58,200 Then to the to the results of this study, you see, the operative term is longer in the Romney procedure, 164 00:18:58,200 --> 00:19:02,280 which is a field of 49 for just two hundred ninety six. 165 00:19:02,280 --> 00:19:08,010 And you see that in actually all the robotic literature probably has to do also was a changing of 166 00:19:08,010 --> 00:19:15,660 the instruments and the the more precise of the surgery that you are performing with the robot. 167 00:19:15,660 --> 00:19:28,710 Blood loss was significantly less in the robotic group of 400 versus 500, the 68, and we had hardly any conversions. 168 00:19:28,710 --> 00:19:32,370 The main outcome the primary outcome of the study was overall complications. 169 00:19:32,370 --> 00:19:39,210 And you see this is significantly less in the robotic group of 59, which is 80 percent. 170 00:19:39,210 --> 00:19:44,550 This includes all the complications. If you look more closely into the most common. 171 00:19:44,550 --> 00:19:56,470 This is the pneumonia and pulmonary complications were significantly less in a robotic group 32 versus 58 percent. 172 00:19:56,470 --> 00:19:59,680 If you look to cardiac complications and this is also, I think, very interesting, 173 00:19:59,680 --> 00:20:06,100 it's mainly and for fibrillation, there is 22 percent versus 47 percent. 174 00:20:06,100 --> 00:20:11,390 So there's also significant reduction in cardiac complications by M. Invasive surgery. 175 00:20:11,390 --> 00:20:21,430 You're, of course, operating over the heart of the pericardium, which cause maybe the atrial fibrillation in. 176 00:20:21,430 --> 00:20:28,760 So you can the 50 percent reduce this complication by many more invasive surgery? 177 00:20:28,760 --> 00:20:36,350 Than to wound infections. There was a trend also to less wound infections in the water group. 178 00:20:36,350 --> 00:20:38,660 This was not significant. 179 00:20:38,660 --> 00:20:51,100 And especially in the terrific part, you see there is no one defection after the invasive surgery versus nine percent in the open group. 180 00:20:51,100 --> 00:21:01,090 Then to the functional recovery, I think this is also very interestingly defined not only the day of discharge but also the functional recovery, 181 00:21:01,090 --> 00:21:08,230 meaning that the patient is able to walk and to eat independently without any drains. 182 00:21:08,230 --> 00:21:17,650 And this was also within two weeks in 70 percent of the cases, with robotic fresh 50 percent in the group, 183 00:21:17,650 --> 00:21:26,020 significantly different functional recovery and the course of the procedure were calculated and they were not significantly different. 184 00:21:26,020 --> 00:21:35,180 This includes not only the machine, but also the instruments, but also the cost for the hospital stay and the management of complications. 185 00:21:35,180 --> 00:21:41,920 And because you have a higher complication, rates cost equal out, then quality of life. 186 00:21:41,920 --> 00:21:51,880 We looked into two time periods at discharge and after six weeks following surgery and as an older man's physical functioning. 187 00:21:51,880 --> 00:22:02,680 Also, health related quality of life was significantly better in the M.E of age group at all time points than postoperative pain. 188 00:22:02,680 --> 00:22:13,990 We had exactly the same pain regimen in both groups with epidural catheter and the PCI and PCI in in all cases. 189 00:22:13,990 --> 00:22:16,660 But but still you see that that old time points. 190 00:22:16,660 --> 00:22:29,090 The minimum invasive surgery group has less pain than the open surgery group that continues until two weeks after the surgery. 191 00:22:29,090 --> 00:22:36,560 Then the oncological outcome, we looked at all the parameters and we didn't see any difference between the oncological outcome. 192 00:22:36,560 --> 00:22:40,010 So that's actually what you would like to see no difference in. 193 00:22:40,010 --> 00:22:47,390 Well, look, go back, no difference in our zero rejection rate, which was about ninety three ninety 96 percent. 194 00:22:47,390 --> 00:22:53,270 And also the number of lymph nodes, which was twenty seven and twenty five percent in both groups. 195 00:22:53,270 --> 00:23:01,820 So no compromise in oncological outcome. This also translates into survival, with a median follow up of thirty eight months. 196 00:23:01,820 --> 00:23:12,570 You see that the survival curves are parallel and about 50 percent five year survival in both groups. 197 00:23:12,570 --> 00:23:23,580 So conclusion of this trial is that the minimum wage of robotics was open is improving postoperative outcome, a lower percentage of complications, 198 00:23:23,580 --> 00:23:28,440 lower cardiopulmonary complications and less pain, better quality of life, 199 00:23:28,440 --> 00:23:37,440 better short term functional recovery cost equal and oncological comparable. 200 00:23:37,440 --> 00:23:46,200 And what our future developments are will hopefully have time to show you a short movie of our technique of T for B, 201 00:23:46,200 --> 00:23:55,140 that means the tumour is invading the adjacent organs in most of the time in the talks after chemo radiotherapy you can downstage, 202 00:23:55,140 --> 00:24:04,590 you can with this technique, even in upper mediastinal tumours, you can dissect it because you see it so well and you have all the dexterity. 203 00:24:04,590 --> 00:24:10,860 We do a hand-sewn introduction on this. The most is and we have introduced with the new robots the four arm technique because 204 00:24:10,860 --> 00:24:15,800 you have your are dependent on the intercostal space with your troca positioning. 205 00:24:15,800 --> 00:24:26,340 It's not so easy to have four arms, but with the new robotic systems with the very elegant and small arms, you can do that. 206 00:24:26,340 --> 00:24:36,060 And also the abdominal phase was now introduced robotically because of the multi quadrant capacity of the new robotic systems. 207 00:24:36,060 --> 00:24:42,630 And finally, we are training our other centres and also training fellows and residents in this technique. 208 00:24:42,630 --> 00:24:52,530 This was a major next step. I think this is the robotic DaVinci Ixion with a completely new concept of the arms of the robotic arms. 209 00:24:52,530 --> 00:25:01,150 Very elegant and with a lot of dexterity and really designed for multi quadrant surgery. 210 00:25:01,150 --> 00:25:06,400 That means that we can now use four arms techniques, 211 00:25:06,400 --> 00:25:12,970 and this makes the surgeon really independent of the assistance, the table assistant is not so important anymore. 212 00:25:12,970 --> 00:25:16,450 You don't need any clipping anymore. You don't need any cutting. 213 00:25:16,450 --> 00:25:22,150 The only thing the table situation now does, and I think a script nurse can do that is the suction. 214 00:25:22,150 --> 00:25:33,970 So you're not dependent on the second surgeon. You can really operate and you can expose your own field without without an assistance. 215 00:25:33,970 --> 00:25:35,110 This is the poor positioning. 216 00:25:35,110 --> 00:25:43,720 Be designed for the four arm technique and again, little bit different, but also the same principle as we had with the three arm technique. 217 00:25:43,720 --> 00:25:51,640 But you look into a curve the positioning of your toe course in order not to have any collision. 218 00:25:51,640 --> 00:25:55,240 And this is the the setup we have in Utrecht. 219 00:25:55,240 --> 00:25:57,400 We have a dual control system. 220 00:25:57,400 --> 00:26:04,870 The advantage is that you have the surgeon and you can have an experienced surgeon if you have a difficult case to help each other, 221 00:26:04,870 --> 00:26:09,730 for example, but it's especially used for training purposes. 222 00:26:09,730 --> 00:26:15,670 So you have the ability to take the arms for a short period of time or two to point with. 223 00:26:15,670 --> 00:26:21,640 You have a pointer 3D printer where you can guide the trainee through the 3D operation. 224 00:26:21,640 --> 00:26:27,100 It's really an excellent way of of training surgeons. 225 00:26:27,100 --> 00:26:33,160 This is the abdominal positioning we use actually a straight line for the abdominal ports. 226 00:26:33,160 --> 00:26:37,990 And we use liver retractor, so you don't need to have. 227 00:26:37,990 --> 00:26:46,360 You can also start using the fourth arm as a liver objective. It's much better to have the fourth arm if as an active surgical arm. 228 00:26:46,360 --> 00:26:54,510 And this is the the abdominal poor positioning and the phenomenal setup of the of the patient. 229 00:26:54,510 --> 00:26:59,850 Then I'd like to show you a few films, short movies. 230 00:26:59,850 --> 00:27:11,400 This is the abdominal part and you can see we all have the gas, the conduct and you see this is very nice. 231 00:27:11,400 --> 00:27:16,050 You have a wristed stapler. So this is a robotic wrist. 232 00:27:16,050 --> 00:27:22,350 It's very, very exactly control the the angle of your stapling. 233 00:27:22,350 --> 00:27:30,340 And this was the guest economy that just shows you this is the Linfen activity we're running over the station age. 234 00:27:30,340 --> 00:27:35,040 This is the common hepatic artery towards the portal vein. 235 00:27:35,040 --> 00:27:41,520 So a very short clip just to show you how you can can do this abdominal abdominal phase. 236 00:27:41,520 --> 00:27:46,770 And this is the the setup we have in our old car or in Utrecht. 237 00:27:46,770 --> 00:27:51,660 We start here, you look towards the vertebral column of the patient. 238 00:27:51,660 --> 00:27:53,430 So you really have to adapt to this anatomy. 239 00:27:53,430 --> 00:28:01,740 Also, you see older structures very much enlarged and you really have to to get used to that and take the advantage of that. 240 00:28:01,740 --> 00:28:07,440 This is the wristed instrument showing the Humalog clips of the crossing, the zygier's vein. 241 00:28:07,440 --> 00:28:14,820 We're looking down to the upper mediastinum and the dressing in that you can see you can see because you see the plane so well, 242 00:28:14,820 --> 00:28:19,290 you can now remove over the trachea sparing. 243 00:28:19,290 --> 00:28:24,660 This is the recurrent nerve at the left side pointing upwards. 244 00:28:24,660 --> 00:28:30,390 So you can do a very extensive para tracheal lymph connectome at both sides. 245 00:28:30,390 --> 00:28:36,440 Shapiro cable vein running over disappear. OK, vein at the right side at the left side is a joke. 246 00:28:36,440 --> 00:28:45,420 Here you see the vagus nerve, the trachea at the upper Torres Inlet, and you see that there is a lot of dexterity. 247 00:28:45,420 --> 00:28:52,110 This is a vessel seated bipolar device that can congratulate the structures. 248 00:28:52,110 --> 00:28:57,420 This is the vagus nerve and the right side where we're running over. 249 00:28:57,420 --> 00:29:02,760 We cut the vagus nerve just below the right main bronchus. 250 00:29:02,760 --> 00:29:07,470 And here at the level of the diaphragm is the thoracic duct, 251 00:29:07,470 --> 00:29:18,350 which is encircled and is taken with the specimen and is with again the restored clipping device is. 252 00:29:18,350 --> 00:29:26,930 Is there to take off the clipping you, you see the thoracic duct. Now we have lifted at the level of the diaphragm, you have lifted the oesophagus. 253 00:29:26,930 --> 00:29:34,220 As you can see, you can take the vessel sealer as a as a retraction device and we move over to pericardium, 254 00:29:34,220 --> 00:29:38,480 which is down below to the coronial sip coronial notes. 255 00:29:38,480 --> 00:29:42,440 This is the right main bone because you see the cartilage of the Rypien bronchus and you 256 00:29:42,440 --> 00:29:49,250 can see how you can move over the right and left main bronchus taking all the tissue out. 257 00:29:49,250 --> 00:29:54,530 This is the gash. The comedy was created in the abdomen and we take it up into. 258 00:29:54,530 --> 00:30:01,760 The oesophagus is dissected and we measure the level of the anastomosis we use. 259 00:30:01,760 --> 00:30:12,950 ICG and the ICG is used as a measure of the vasculature of the conduit in case we have a vascular top. 260 00:30:12,950 --> 00:30:15,980 We will. We will staple it off. 261 00:30:15,980 --> 00:30:25,580 This is the similar technique we use nowadays, which is a handsome technique with a running suture, posterior and anteriorly. 262 00:30:25,580 --> 00:30:30,920 And this is a bracketed suture. So you have like a v lock. 263 00:30:30,920 --> 00:30:43,820 This is a strata fixed suture and we use V and the anaesthetic technique with amount of plastic surrounding the anastomosis. 264 00:30:43,820 --> 00:30:50,350 I hope you can see the rest of the instruments really help you. This is we were in the upper and upper mediastinum. 265 00:30:50,350 --> 00:30:54,680 Now we are down below the diaphragm doing a cruel plastic. 266 00:30:54,680 --> 00:31:02,890 And this is the end of the thoracic procedure where you have everything done. 267 00:31:02,890 --> 00:31:07,060 Then I'd like to show you an experiment we do with ICG. 268 00:31:07,060 --> 00:31:16,030 This is a fluorescent substance that was injected preoperatively the day before surrounding a tumour, and we are looking now at the Seelig trunk. 269 00:31:16,030 --> 00:31:17,740 And you with a light images, 270 00:31:17,740 --> 00:31:25,210 it's very difficult to distinguish the lymph nodes and to to distinguish that from the pancreatic tissue in a fatty tissue. 271 00:31:25,210 --> 00:31:37,870 But with the as you can see here with the ICG, you see a lymph node appearing there that was actually, uh, just at the border of the pancreas. 272 00:31:37,870 --> 00:31:43,360 Not so easy to distinguish, actually impossible to distinguish without ICG. 273 00:31:43,360 --> 00:31:51,250 And you can take it this way. You can really identify lymph nodes that you couldn't see before, and we use it now in early tumours. 274 00:31:51,250 --> 00:32:02,260 We have a group of patients that were treated with ESD, and they had bad histological logical characteristics, and they need a lymph node next to me. 275 00:32:02,260 --> 00:32:12,790 And we use this now as an experiment. Then to conclude, I would like to show you our programme of proctoring and training this technique. 276 00:32:12,790 --> 00:32:21,880 This is the group of Bruno also is as part of this issue, very nice group of European, um, minimally invasive oesophageal surgeons. 277 00:32:21,880 --> 00:32:27,580 We had several meetings and we have a meeting this year again in Munich next month. 278 00:32:27,580 --> 00:32:36,220 We come together and discuss various topics on this technique and really aiming for the dissemination of this technique. 279 00:32:36,220 --> 00:32:42,620 And one of the things we did was the finding in Adelphi consensus meeting the 280 00:32:42,620 --> 00:32:48,070 the way you could build up a structured training programme for this technique. 281 00:32:48,070 --> 00:32:53,800 And we came up with several items and a summary of that is the what is it? 282 00:32:53,800 --> 00:33:01,150 What is the what is mandatory for a team to start up this technique? You should have these have two surgeries dedicated to this technique. 283 00:33:01,150 --> 00:33:06,310 I think otherwise it's you should really have support of your your team, 284 00:33:06,310 --> 00:33:14,350 preferably also dedicated anaesthetist and scrub nurses because you don't want to wait all the time for the setting up of the system. 285 00:33:14,350 --> 00:33:20,950 You want to have a smooth programme running and and then you have the dedication is very key for this. 286 00:33:20,950 --> 00:33:29,590 Then the sufficient caseload, I think in the UK, there's no discussion about it, but there are countries where there are hospitals doing less than 20, 287 00:33:29,590 --> 00:33:33,820 and if you have less than 20, you take too much time to get through your learning curve. 288 00:33:33,820 --> 00:33:38,920 So we decided at least 20 cases a year. You need to to start this programme, 289 00:33:38,920 --> 00:33:48,340 and this is very important for your board of directors that you have a guaranteed access to the system because if you do some cases and then months, 290 00:33:48,340 --> 00:33:57,150 you don't do anything, then you really have to start up again. There is a simulation programme that you can do in between, but it's, I think, 291 00:33:57,150 --> 00:34:03,220 very important to have access weekly access to this, to this reporting machine. 292 00:34:03,220 --> 00:34:09,640 Then what about the programme we have run running that been running now for the past years? 293 00:34:09,640 --> 00:34:17,080 It started with the case observation team comes to the expert centre and to observe, preferably with the whole team, 294 00:34:17,080 --> 00:34:23,770 the the procedure and the one or two times is, I think, an excellent way to start a programme. 295 00:34:23,770 --> 00:34:29,260 Then we advise to do go for a basic course, basic robotic course. 296 00:34:29,260 --> 00:34:38,560 Also, the basic training course, as we are running in Utrecht, was endorsed by Esso and just analysing the technique was lectures, 297 00:34:38,560 --> 00:34:44,890 was hands on experience and then after that to do a specialised cadaver training where you have 298 00:34:44,890 --> 00:34:51,940 the access and the hands on with the proctor during the day to go through the whole procedure. 299 00:34:51,940 --> 00:34:58,750 After that, the boxing programme is started on site and the proctor is coming to the through 300 00:34:58,750 --> 00:35:05,470 the unit of the trainee and is getting through to the cases step by step, 301 00:35:05,470 --> 00:35:10,990 preferably during the period of of some weeks. 302 00:35:10,990 --> 00:35:14,920 This is the training programme we are running since 2009 in the Netherlands. 303 00:35:14,920 --> 00:35:16,210 It's in the Utrecht. 304 00:35:16,210 --> 00:35:26,290 It's it's a it's a yearly programme of two days and we trained all the surgery in the Netherlands and now training with the endorsed, 305 00:35:26,290 --> 00:35:30,310 of course, also surgeons worldwide in this technique. 306 00:35:30,310 --> 00:35:37,630 The next course is March five to six, 2020. 307 00:35:37,630 --> 00:35:45,700 This is how it looks like we have a skills lab where we have also a cadaver facility, 308 00:35:45,700 --> 00:35:54,940 where you have small groups with each of them, a proctor will guide you through the system and through the technique. 309 00:35:54,940 --> 00:36:03,840 And we have now several we have now several of those robotic systems as well available. 310 00:36:03,840 --> 00:36:10,200 And this is an artificial model where you can train the suturing robotically, 311 00:36:10,200 --> 00:36:15,600 and here you can see also some some other models that you can use for your training. 312 00:36:15,600 --> 00:36:20,040 And I think especially also the now the simulation programme that is available 313 00:36:20,040 --> 00:36:27,360 on the da Vinci robot is excellent for you for training your your skills. 314 00:36:27,360 --> 00:36:35,160 What are we doing now? We have had more than 40 teams coming over and we have three teams in the Netherlands trained. 315 00:36:35,160 --> 00:36:42,610 There are also some teams that we trained that are now put Proctor for intuitive and are training on a teams in the Netherlands. 316 00:36:42,610 --> 00:36:50,580 I think now in total, there are about five teams, two teams on the way and three three four teams in the Netherlands and the UK. 317 00:36:50,580 --> 00:36:56,940 And we have very recently and a second team that now finished and two are on the way. 318 00:36:56,940 --> 00:37:08,350 And in Germany to finish and one is underway and this is the group of of countries and surgeries that fish this over the past two years. 319 00:37:08,350 --> 00:37:12,010 Then this is also a very exciting and crisis here. 320 00:37:12,010 --> 00:37:16,120 And he is the first. He is the fellow. 321 00:37:16,120 --> 00:37:22,030 We designed the fellowship programme because trainee surgeons, I think, is very important. 322 00:37:22,030 --> 00:37:30,850 But training fellows even may be more important to train them and have a year of experience and really 323 00:37:30,850 --> 00:37:38,110 hopefully have them ready to set up and to help setting up a programme at their home institute. 324 00:37:38,110 --> 00:37:46,660 And this was the reason for this European myI Fellowship and this is fresh use on the website. 325 00:37:46,660 --> 00:37:54,420 And he has already done his basic course so you can see on the left side and here you see, he is really part of the group. 326 00:37:54,420 --> 00:38:04,010 He's really, really happy to have him. Yeah, I'm really grateful that we were able to have to have such an intelligent young surgeon with us. 327 00:38:04,010 --> 00:38:13,670 You see, don't love visiting us a few weeks ago and you see the whole group you're dressed. 328 00:38:13,670 --> 00:38:16,010 So another thing is the air, 329 00:38:16,010 --> 00:38:25,280 which is the Upper GI International Robotics Association found it's very recently also dedicated to the dissemination of this technique. 330 00:38:25,280 --> 00:38:29,270 And this is another fellow. 331 00:38:29,270 --> 00:38:34,250 This is Peter from the sloughs, and he's the first author of our robot trial. And this is Peter Grimier. 332 00:38:34,250 --> 00:38:42,570 We trained him now three years ago in and Brahmi, and he was already done within two years, more than 100 cases. 333 00:38:42,570 --> 00:38:46,160 I think that's really a very successful programme. 334 00:38:46,160 --> 00:38:54,530 He's now official, Proctor also for four robotic origami procedures and you have he has Peter from the stage as his fellow. 335 00:38:54,530 --> 00:39:05,300 So we're very proud of that. I think we can I can finally show you this my last video. 336 00:39:05,300 --> 00:39:10,370 This is an advanced case of T four B cancer. 337 00:39:10,370 --> 00:39:23,270 And oh, and this this shows you actually in the ultimate form of how you can use robotic techniques. 338 00:39:23,270 --> 00:39:31,250 You see a lot of that positive knowledge in the upper mediastinum. This patient was treated with chemo radiotherapy and had a ibas. 339 00:39:31,250 --> 00:39:46,040 So, um, showing that there was a growth in the trachea restage after the adjuvant chemo radiotherapy and then was downsized, 340 00:39:46,040 --> 00:39:51,770 but still had positive pet positive notes on this on this pet scan. 341 00:39:51,770 --> 00:40:05,390 So we we did a rejection. And this is something I would, I think, really showing you the benefits of this technique. 342 00:40:05,390 --> 00:40:10,610 This is our old or I always draw the poor positioning. 343 00:40:10,610 --> 00:40:19,710 I think every patient has a different than enemy and it's always important to really draw exactly the ports. 344 00:40:19,710 --> 00:40:43,160 On the basis of some landmarks. This is the S-i system that was we used before. 345 00:40:43,160 --> 00:40:50,350 And you see the way you can manipulate the instruments in a console. 346 00:40:50,350 --> 00:40:55,240 Now we're looking again at the level of the pericardium. 347 00:40:55,240 --> 00:41:04,750 This is at the level of the diaphragm again, you see. We do the cutting of the crossing, a zygier's arch. 348 00:41:04,750 --> 00:41:11,340 This is done with the hemlock. You can see how very nicely you can restore the instruments. 349 00:41:11,340 --> 00:41:20,420 And here again, you can see how we can. We can move over to, as, I guess, fame. 350 00:41:20,420 --> 00:41:39,270 And then you get to the after getting all the lymphatic or the lymphatic tissue that that can contain lymphatic metastases. 351 00:41:39,270 --> 00:41:47,400 Here we are in the sub Coronil area. And there was a lot of reaction because of the chemo radiotherapy. 352 00:41:47,400 --> 00:41:52,130 This patient did a lot of oedema, but. 353 00:41:52,130 --> 00:42:01,460 Because you see, it's 10 times in large, you can very precisely move along all the area, all the in the vital organs you see here, 354 00:42:01,460 --> 00:42:08,870 the left main bunkers, you see the whitish coring of the tissue, which is typically after chemo radiotherapy. 355 00:42:08,870 --> 00:42:17,870 It's a very strong reaction you have of the tissue, but because you see it so well, you can very precisely move over the member in this part. 356 00:42:17,870 --> 00:42:21,890 And this is the structures we identified as the Mesereau's all figures. 357 00:42:21,890 --> 00:42:34,640 You see you open up to the fascia and then you come into a plane with the lymphatic and also the and the are the direct auto itself to your branches. 358 00:42:34,640 --> 00:42:37,550 This is the upper mediastinum and this is the tumour. 359 00:42:37,550 --> 00:42:46,740 You can still see at the very much connected to the memories part of the trachea because you see it so well, 360 00:42:46,740 --> 00:42:54,810 you can exactly with your hook up very, very localised energy transfer of the DETERMINA. 361 00:42:54,810 --> 00:43:06,110 You can dissect it of the member in this part of the trachea without damaging the. 362 00:43:06,110 --> 00:43:16,550 And you see that in the upper mediastinum, there were still some positive notes, very strikingly positive notes. 363 00:43:16,550 --> 00:43:25,680 That were dissected, this is the the left side of the turkey and the turkey is pushed downwards with the suction. 364 00:43:25,680 --> 00:43:30,360 And here you see the superior cable vein along the superior cable vein and the turkey 365 00:43:30,360 --> 00:43:56,490 also and large positive notes that can be dissected along the right recurrent nerve. 366 00:43:56,490 --> 00:44:03,820 And I think what is really striking that you hardly see any blood and that's the reason you because you're following all the planes, 367 00:44:03,820 --> 00:44:10,710 um, there's virtually very little blood loss in this is difficult procedure. 368 00:44:10,710 --> 00:44:18,240 There is this is the area of the subclavian vein and artery where the recurrence right recurrent nerve is running. 369 00:44:18,240 --> 00:44:26,710 So over the right trigger and nerve and enlarged lymph nodes are dissected as well. 370 00:44:26,710 --> 00:44:30,820 And this is the image of the waterways, the intercoastal arteries. 371 00:44:30,820 --> 00:44:38,140 This is the the image you get when you have a radical than a radical limb for the next to me with unblock, 372 00:44:38,140 --> 00:44:43,390 this section of the oesophagus and the lymphatic over the period kadhim over the aorta. 373 00:44:43,390 --> 00:44:56,000 The left pleura there. And the is the ship Gravano, the ship Chrono, our notes are on block dissected. 374 00:44:56,000 --> 00:45:12,370 You see the the pointed right and this is the pulmonary vein and the right and the left main bronchus. 375 00:45:12,370 --> 00:45:24,002 OK. There was a thank you very much for your attention.