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Four are Corcoran Memorial Lecture.

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So I wanted to start by just giving an explanation of what the series of memorial lectures is.

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So this is this year's Corcoran Memorial Lecture.

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It's named in the memory of Stephen Corcoran, who was a graduate student in the Department of Statistics until his death in nineteen ninety six.

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He had been an undergraduate at Oxford and got first class honours in mathematics in nineteen ninety one.

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Then he went and studied for a diploma in mathematical statistics at Cambridge and returned to study for his DS fill in statistics at Oxford.

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And every other year we have a Kroeker memorial prise.

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But. Without fail, annually, we have a corporate memorial lecture.

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So this year we do. It is not a prise year. So we had free reign to choose the topic of our speaker.

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And so we asked Karen Magnuson to come in and speak yesterday.

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So we're very pleased that she agreed to do so.

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She is a distinguished professor of statistics at Queensland University of Technology, which is in Brisbane, Australia.

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She is the deputy director of the Australian Research Council Centre for Excellence in Mathematical Frontiers.

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She's a fellow of the Australian Academy of Science and the Australian Academy of Social Sciences.

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She's also a member of various national and international statistical societies.

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She has wide ranging research interests in both mathematical statistics and its applications in areas including health, environment and industry.

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In particular, she focuses on Bayesian methods. So she has very kindly agreed to present to us today.

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And so we have this morning scheduled lecture because she is speaking to us from Australia in these covered, restricted times.

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So I'm just about to hand over to her. We will have a question and answer session at the end.

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So if you have questions, please types them into the chat and I will read them out to her or a selection of them,

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because we probably won't be able to answer all of them at the end.

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And otherwise, thank you very much for joining us. And I will hand over to Kerry for the lecture.

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Thank you very much, Crystal, and thank you very much for the invitation to present this lecture.

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And and thank you to the people who have given up some morning time to attend.

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As you heard in Australia, it would be great to be there. But but in fact, this is the way it is at the moment.

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So I'd like to just share my screen. And.

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And. And we'll talk to.

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Can you see my screen? Yes. That's great. Okay.

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Thank you. So I'd like to talk to you about not aggregating data,

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and I'm going to do this by first presenting a couple of case studies where the imperative for this.

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This area of work has come about. And then I'd like to talk about some of the work in progress in this area.

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So this is a new work that we're doing.

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And if people are involved in this or have some suggestions or comments, then I'd be very excited to hear about them.

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It's certainly not complete at the moment. So the first the two case studies,

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the first one is the Australian Cancer Atlas and the Australian Cancer Atlas

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was is an interactive online atlas that gives brings together cancer data,

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GISS location details, digital earth technology and statistical models to provide an online interactive map of cancer.

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About 20 cancers in Australia at the small area, a two level.

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So there's about two thousand of these areas across Australia.

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And this map is based on the underpinning technology or modelling in this atlas is a Bayesian statistical model.

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So we have here why eyes the number of cancer cases in a small area and why is the expected number of cancer cases in that area?

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Agent six matched. This is, of course, on models. So we model our number of cancer cases as on.

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And we have each of the new eye being the the relative risk of the kind of cancer in that particular area.

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So you are then is modelled in terms of some potential covariance EXI and also a spatial term S.I.

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So this spatial term is going to incorporate the information of the neighbours in the area.

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Given that we are in geographical space, so we have a number of options for that spatial term.

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For example, a base egg yolk Mollee,

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a model proposed by basic getable in nineteen seventy four is is has a term splits up that aside, the residual into two parts.

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One is the, the spatial component UI and one is an unstructured component A.I. and the UI is then the spatial components depend on the neighbours,

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you Tilda Eye. And so it's going to be normally distributed.

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That random effect is going to be normally distributed based on the average of the the random effects in the neighbourhood of UI.

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Now an alternative to that is from Leroux in two thousand and his colleagues.

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And here we model Essi as you are and you are has two components.

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One has a it's almost like a mixture.

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So it has a component that has something to do with the spatial neighbourhood and also a component that is the overall variance.

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And this then allows us to have some we have this mixture model that is governed by a parameter ROE,

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which says how much weight we want to put on the the neighbourhood.

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The special neighbourhood. And how much we want to regress towards the overall mean.

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I know this LaRue model, Ben has only this one parameter, Roe,

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and turns out to be quite a good model for the kind of spatial analysis that we want to do in the Cancer Atlas.

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So the Cancer Atlas then, as I said, is this online model,

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and I'll just show you some of the features of it, you can you can pull down any of the cancers you like.

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You can get information from those cancers,

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in particular the visualisations about the probability of being above the national average or below the national average.

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And we're talking here about uncertainty and estimates and we're also talking about probabilities.

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And so we're also able to compare areas and and provide the information as well in the

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form of Fantham modelled estimates at the small area level survey Cancer Atlas has been.

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We're going to extend this to space time and.

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And already it's shown quite a lot of information in terms of, for example, spatial inequalities.

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So this chart, he has showed us the difference between major cities,

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regional and remote areas, in terms of for females, for different kinds of cancers.

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And you can see here some really startling differences in the standardised incidence rate on the left axis there.

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This is all compared to the the national average, which is one some stark differences for people in remote areas.

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You can also get from this information.

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And we've been able to provide relative survival curves and relative survival estimates for each small area level.

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And we can then look at localised and advanced relative survival curves and the differences between the different areas.

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So remote areas and cities. And you can see here that there is this kind of real difference that this that lets us being able to to reveal.

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And we can ask questions like how many premature deaths could be prevented if there were no spatial inequalities.

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And so before by being able to quantify these terms,

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then this is really led then to and a real media release or real public acknowledgement of differences,

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spatial differences in cancer across our country.

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It's also led then to a changing government policy in terms of the Treb travel subsidy for people in the push to get treatment in the city.

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So we think this is successful.

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And what's interesting for us is that this is a product that has underpinning it a spatial statistical model, a Bayesian model.

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Now, we've also been looking at just more recently,

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spatial Bayesian empirical likelihood so we can avoid some of the parametric assumptions in in our modelling.

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And so the model here looks the same as before. But what we're going to do, instead of assuming a normal distribution for the low relative risk,

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we're going to have estimating equations and I use these estimating equations to be able to derive our parameter estimates.

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So we have the typical estimating equations here.

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We're going to have the constraints on the main and the variance. And then we we also have priors on this and we can obtain the estimates.

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So the new part here is,

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is including the spatial random effect in these empirical likelihood models and the kinds of priors that we can have for our random effects of,

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for example, an independent Gaussian prior excuse, the spelling of Gaussian.

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We have conditional order, aggressive price like the way I am and LaRue as before.

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We also have, for example,

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a generalised moron basis prior that has been used in previous work on spatial empirical likelihood in the paper water et al.

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So there's not a lot of work on spatial empirical likelihood.

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And this was a contribution to that effort.

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The speed at the stimulation results, when we look at the the the empirical likelihood approach compared with the parametric approach.

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You can see here in a simulation study where we have hired a correlation, low order correlation and also outliers.

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And we have that for small a small number of areas and also a larger number of areas.

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It turns out, as we might expect, that the the empirical likelihood approach really shows its colours when either we have a small number of areas.

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And so the normality assumptions may not hold out or we have these outliers.

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So when we had this 20 percent of outliers, then our base empirical likelihood approaches seem to outperform the parametric approaches.

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So this has promise for our atlas. Now, that's fine in terms of being able to model.

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But but one of our concerns still in this is.

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The issue that we needed to aggregate the data now Australia is based on a number of states.

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Each of those states holds the data and we needed to have agreements with each of the

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states in order to be able to bring those data together and then to create the models.

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Now, this has to happen regularly. And if we want to change anything or obtain new data, we need to go through those agreements again.

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There are very real issues of privacy and there are also issues of of obtaining permission to for these data.

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So the methods that we have at the moment don't address those issues.

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They certainly address the privacy issue in terms of providing the information at the small area level.

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But we still need to aggregate the data into one database. Our second case study here is the Virtual Reef Diver Project.

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So the Great Barrier Reef is one of the world's treasures.

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It's two thousand three hundred kilometres long and there is monitoring at certain sites along the reef.

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But there is a lot of area where there's no monitoring.

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So what can we do in those areas in order to be able to help us to develop accurate and useful predictive models across the whole of the reef?

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Well, this underwater drones, the satellite imagery, and there's numbers of divers who are out there collecting information.

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So we built an online interactive reef.

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So it's called virtual reef diver. We are inviting organisations and citizens to contribute or geotag their photos, the images of the reef.

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And we are also asking citizens to go into the into the images and annotate them.

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So if you are interested in contributing to the beach, the health of the Great Barrier Reef, please visit Virtual Reef, Dorell or you.

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Now, what we have then are these images which you can download the images of the underwater images of the reef.

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And then also classify them. So we ask citizens to annotate the.

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The circles here as to whether these are coral algae, sand and so on.

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And we can use that information to improve our statistical models.

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There's a huge impact of this work.

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This this project was selected as one of the three shortlisted for the Eureka Prise in Australia here last year, which was very exciting to us.

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So we have citizen scientists who can annotate the images and we can use those annotations in their own right.

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But we can also use them to test for automated image classifications.

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So machine learning and statistical methods.

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And you can see there the list of all kinds of statistical methods that we've looked at for classifying images in the environmental space.

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But then also in the medical space now, at the last of phase is matrix facts factorisation.

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And I'd like to just concentrate on that for a moment. So in particular, we've been looking at Canalis sparse Bayesian matrix factorisation.

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So the aim here is to extract low rank or sparse structures.

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So, for example, our classes in our image and we're going to use matrix factorisation techniques to do it.

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So we have data, which is why an M by N matrix like an image.

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And this can be the the the values that each of the pixels in the image.

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And we want to recover. Then the low ranked matrix X where we have Y equals X plus eight.

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And this X is going to be then decomposed into two vectors.

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You and V. And these vectors, you and V are going to be much smaller than the original Matrix X.

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So you if we have X being M by N, then we have we have V, for example, being in by R.

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And we have sorry you being in by R and V.

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Being in by R as well. And so when we put this together, the R here is much smaller than M or N.

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And then this induces sparsity into this. This low rank approach.

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Now we also can use our priors to induce sparsity.

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So we have calcium price for the columns of U and V. As you can see here.

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And one of the features of this approach is that we have the same the same parameter,

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Gamma J, which is going to appear in both the the variance for you and say this.

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Then we can control that gamma J. To induce the sparsity.

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So we have the prior on the gamma has a gamma distribution and the hyper parameters of that prior distribution are going to be small.

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And this is the way that we can really induce the sparsity in you and V, we coupled you with a kernel matrix K.

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And that gives us a light matrix G. And this G then has a prioress you can see here.

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Now we also then have Jefferys prise on the other parameters here.

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So we also can do the same kind of a prior for V as well.

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So just to complete the model, we then have a residual turn and we have a prior on as well.

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But we're focussing really on that you and be here. And so just to show you a graphical model of what we're doing here,

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we have y y is going to now be governed by G M and H dot n and G dot m is going to be a combination of K, you and U M and Hijau N is K, V and V.

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And then these are the hyper parameters on the swell. So these some we're going to induce the sparsity through these Prior's.

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We have conditional and joint distribution.

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So we have a conditional distribution for our observational model, which is going to have this G and the H there and terms.

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And we have then a joint distribution, which is, of course, is going to be the product of each of these individual distributions.

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We can use variation or base then to to undertake the the analysis here.

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Now, the choice of colonel here are this many different kinds of colonels, and so for images we want,

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then one that incorporates some similarity of information between patches.

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And so what we want to be able to try to do is to have Patch Group, Matrix factorisation.

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And so we want areas that are similar to to have to be in the same role to to base, to stay together effectively.

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So what we do then is we look at this distances Euclidean distance between a pair of patches.

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This is the D. And we're going to define the similarity between that and the pair of patches as well in terms of that distance D.

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So we have a K, as you can see here, being a function of that Euclidean distance between the pair of patches.

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So we're going to have a pixel and it's nearest neighbours then are going to be modelled as a column vector.

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And we can construct this M by N Patch group matrix Y by grouping the other patches

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with similar local spatial structures in the underlying one in the local window.

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So we're bringing together the m the common information in what we call a patch.

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And since each of these patches then a common then we can induce this low rank sparsity that we wish.

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So the overall algorithm then is to cost the patches with similar spatial structure to form a patch matrix.

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And then we can apply our matrix factorisation approach in succession on each of these patch matrices.

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And then we can aggregate the patches to reconstruct the whole image.

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So this is one approach to being able to deal with a large image in order to be able to understand the low rank of the structures in that image.

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So when we look at virtual reef diver, for example, we might want image restoration,

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we might want classification of components like coral and so on in the image.

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And you can see here the the the utility of this function.

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We have an original image. We've made noise in that image.

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And then we can retain or resurrect that image using this method.

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So the method then allows for integration of side information through the through the patches in first parameters and latent variables,

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including the reduced rank using variation of Bayesian inference.

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And we get this low rank, three sparsity induced by an enforced constraint on those light, very light infector matrices.

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And we can show that this improves on some of the state of art approaches for image restoration tasks.

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So that's great, except we still have the issue of not wanting to aggregate the data in this case.

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We have two issues. One is that these images are quite large.

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And so if we're going to create a single database to to analyse the images, that's going to become very unwieldy very quickly.

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Even analysing a single image is difficult because we've already seen how we break it into patches.

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And then we need to do the analysis on the patches. The second aspect is that we have citizens contributing information.

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Now, again, because of the provenance and the the data laws, the the data ownership laws in the UK, in Europe and in the US.

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And coming into Australia, we're going to be really restricted soon about how we can actually deal with individual people's data.

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So we want to think about ways that we don't. We can't.

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We can avoid creating one database to rule them all.

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So what are our options? If we if we look at this?

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Well, our single database says that we put all the data in a single database and then we do the analysis on that.

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We can also look at distributed computing. So here we can if we have a number of databases and we then can have a centralised computer,

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a centralised source that then distributes the the the the commands to the different databases and then receives the information back.

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So this kind of distributed computing is very useful.

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We have horizontal scalability, which means that we can then add more databases or more nodes to this and this distributed system,

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and then we can obtain more or greater capacity by doing so.

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Of course, that comes at a cost because now we have computational interchange and those computational that overhead may be quite large in some cases.

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So there is sort of it. And there's a utility in having a vertical scalability.

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In other words, a larger database. And then after point, we get to more utility by having this horizontal scalability.

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And there's a huge amount of work on distributed computing.

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You know, this this whole area is in in computer science and in statistical areas that are that focussed on distributed computing.

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We know that we can now we have a greater Folt tolerance in this case of one node pulls over.

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We have the other nodes. There's low latency in this.

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And we can also use methods like shotting and so on. And I'll show an example of that in a minute.

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This distributed computing system as motivated approaches like MAP, reduce, Petchey stock, Hadoop and so on.

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So. This is out two of the approaches.

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Another one is decentralised computing, whereas our distributed computing had a central node that then governed the information guy out and back,

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decentralised computing doesn't do that. So it says the information is processed in the cloud and there is no one actor that owns that information.

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This is led then to new work on distributed apps and also lead has led to edge computing and so many of you that you'll be familiar with this.

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But I'll just explain it quickly. Edge computing is that we don't process the information on the cloud filtered through these remotes data centres,

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but instead we do the analysis in the cloud on the individual nodes and then they are aggregated as needed.

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So this is then led to areas, for example, like Federated Learning and Federated Analysis.

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And so there are lots of advantages in this because this is very much the system that we're in

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with this or the area that we would like to get into with the two case studies that I showed.

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So in the first one, we have the Australian Cancer Atlas,

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where we actually have these different states that would like to retain their data

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and we would like to be able to analyse the data in situ and then bring it together.

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We would also like to be able to add the virtual Raef Diavik case, be able to analyse the the images in a more decentralised manner.

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And also, when we come to integrating personal information,

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then we would like to be able to come up with systems where we can retain the province provenance and the individual privacy of of citizens,

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for example, and subjects in a more broad sense.

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So if we go back to our Australian Cancer Atlas,

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if we look at a single database and we ask the question of how do we retain privacy when we we we have the data at this small area level.

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One option is that we actually analyse it at that small area level and then we're in the business of a single database.

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And so we've been looking at, for example,

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summary data analysis that we might do on the perform on take on the actual modelled estimates at the small area level.

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So a natural way that we might think about this then is through a hierarchical meta analysis where we have our modelled log,

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I ask for each of the essay twos, the small area levels, and we might be interested in remoteness, cities, regional and remote areas.

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And then we have an associated standard deviation for that logger's CSIR.

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That's actually part of the information that's provided from the underlying Bayesian spatial model that I described before.

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So we can set up then a hierarchical meta analysis in that in the way that we have.

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Why then the why? I for particular, within the regions of the cities, the regions and regional and remote areas that's normally distributed with a.

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We imagine that there's some measurement error or some uncertainty around the why I that's described by the signalised Sigma squared IJA,

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Ammu IJA then is going to this has been the the true or longest.

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I ask for a particular region,

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remoteness region and they're going to have an overall value of Theta J and those Theta J then for each of the remote areas

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if we wish can also be considered to be drawls from an overall Lagus I r which is going to be described by theta nought.

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So we have our individual estimates of the log siac for each of the remoteness areas.

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They are drawn from an overall mean log assai our distribution of of Lagus.

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I ask for that particular remoteness area and then the means of those areas.

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Then the remoteness regions come from some overall longest site.

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That then governs the the distribution of bogus areas that governs then b the the the whole structure.

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The sigma squared IJA stain can be related to our observed standard deviations s IJA through the usual course quid association.

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We can also add covariates to this, as you can see in the middle panel here.

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And this is sort of a common approach for analysing auto to add covariance.

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And we can then look at some new work, which is when we look at our spatial Bayesian empirical likelihood approach in a meta analysis context.

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And that's on the right panel there. So this is fine for one approach that we might use for modelling, feed the summary data.

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And so we overcome privacy issues here.

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And we could then also Arius could be more encouraged or different states could be more encouraged to provide information at this small area level.

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And we could perform analysis like this.

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We can show that if we do this, then we get quite similar results in these overall estimates because the remoteness regions like major cities,

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regional and remote, we get here posterior means 95 percent credible intervals and the probability that one region is greater than another region.

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So that the natural outputs from our Bayesian models.

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We also can see then if we go to the individual essay twos and we look at those estimates that we we are getting differences between

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when we analysed the data at the individual level versus when we analyse it at the USA to label this aggregate level as anticipated.

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And we can also see that our out empirical likelihood approach is going to give us quite a

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larger interval or spread of the data compared to our parametric approach as anticipated,

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because they stayed or are quite moderate and don't have those kind of outlaws as quickly as we were talking about before.

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So centralised summary analysis has some benefits and some drawbacks.

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The benefits are that we can preserve privacy because we have this aggregate approach.

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It's a simple model. It's computationally straightforward and fast.

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But there is challenging inferential capability because we're modelling at the small area level.

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And and therefore, we may have we have to be careful of controlling for biases in this case.

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We also have some questions about what can we say about covariance.

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For example, is the spatial distribution of our response consistent with the spatial distribution patterns of our covariance?

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And we have to be careful in what kinds of inferences we can draw.

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And those inferences will change as we change the scale of the data.

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So we're still get to scale this to different states and countries in a hierarchical, which you could imagine and how this would go.

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We add a hierarchy to those models that we've already described.

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We come now to distributed computing and so in distributed computing,

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then we're starting to think about how we don't have to create a single database.

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And I've just put this slide up because this was a burse workshop in Canada.

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I wasn't I wasn't at this workshop, unfortunately, but I just wanted to show you here some of the topics that were covered even in 2008.

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And this was about to start on developments in statistical theory and methods based on distributed computing.

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As I said, this is a huge area in computer science, but also there's a substantial amount of work in the statistical community as well.

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You can see here approaches or focus on statistical methods with computational efficiency,

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with statistical properties, with guarantees about the estimates.

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These things are really important for these kinds of approaches are robust.

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What's the divide and conquer algorithms that really underpin a lot of the work in this area?

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And rights of convergence for our estimate is here. Mathematical theory for deep, convolutional neural networks and distributed learning.

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A lot of work on distributed neural networks. And and as I said, divide and conquer methods, for example,

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for correlated data and spatial creaking, which is of interest for us in our spatial analysis.

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And so you can say here that that there are these kinds of issues in the distributed

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computing that really focus on the statistical underpinnings of these particular methods.

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And again, just pointing out that one of the main approaches here is that the approach that many of us are very familiar with,

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the divide and conquer algorithms. So just as an example of some of this work, we have distributed Bayesian inference s,

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for example, Wang and Dance Donson and there's weighing in this 2015 work.

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We're really we're looking at decomposing the global posteriors.

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So we take the global posterior distribution and we're going to break it up into a product of subsamples posteriors.

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And so that's the second equation that you can see there, which is going to just be conditional on the Z JS instead of all of the data Z,

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so that we have this prior beam that's raised to the power one on K and.

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And we have this DJI, which is a normalising constant. But it really what we're doing here is we've got these subsamples.

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We can start the posterior distributions from those subsamples.

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We bring those together and we weight them according to the.

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So this sort of like this weighted combination or the weighted combination of the likelihoods.

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So this approach then really motivates the macro Joose approach.

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So we run separate Markov chains in parallel on different machines based on the local data.

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We transmit this back to these local posterior draws to a central node.

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And then we combine those jaws to form an approximation or a surrogate likelihood that approximates our true global likelihood.

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So this kind of approach has said Spain. It's familiar to us.

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There's been a huge amount of work over the last 10 years in this area.

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So if we come back to the virtual reef diver approach, we think about how this kind of approach might work.

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In our case, an example I'd like to just talk through with you is where we were looking at crowd sourcing by Mechanical Turk.

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So we wanted lots of citizens now to to classify our images.

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And so we used Amazon Mechanical Turk to recruit people.

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So this is an online system where people often pay, but people will undertake tasks.

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And so here we had we asked them to classify our images.

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Each person was assigned up to 40 images. They were asked to classify points.

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And we paid them for this. We got thousands of people who classify these images.

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And, of course, then we needed to do something with the data. So what we were we and one of the issues is, of course,

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that we need to take into account that the ability of the citizens who are analysing

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these data and we have to take into account when we're looking at their ability.

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The difficulty of the images that we asked them to annotate. So we think that this in a rash model or is a common sort of model to use in this case.

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So this is the item response model and a three parameter logistic crash model is is useful for us.

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So we expanded this model to say, alright, we'll use the three parameter logistic model, we'll add spatially dependent item.

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Difficult is the key to this model. And then we'll also expand it.

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And you give me. Yes, you're back and you left us for a little while.

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And it's no longer secret in sharing. Right, AK.

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Great. Thank you. But today, I get to it's.

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Okay, so. Okay. Thank you.

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All right.

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So we want to be able to analyse the data from the citizens and so we can use this three parameter logistic resh model that has a spatial term in here

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in the spatial term is going to be based on the images and say images in a particular area are going to be similar in terms of their difficulty.

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And this kind of model then allows us to identify the latent ability of each of the uses,

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adjust for the difficulty of the the images also allow for discrimination parameter.

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So that's how quickly we we can we were changing the probabilities and also account for guessing or pseudo guessing in this case.

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And so what we want to do here is we want to be able to identify the abilities of each of the citizens and adjust for that.

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So what we can do if we if we do that, I'll just show you here,

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is that we can say we can estimate the ability and this some this thought here shows that we did quite well in that.

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So we have some test data. We can assess their their ability.

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In a small sample of the cases, we looked at their estimated ability and we can pretty much get that right from this approach.

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So this means then that we can only take the people who are doing a good job, who have high ability,

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and if we can also identify training or personalise the training for our citizens.

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So the options here when we have all of this information is again a divide and recombine approach.

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And so we divide it into if we were to use a common divide and recombine approach, we'd split into multiple shards or subsets.

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We'd fit the model two into independent subsets on independent machines.

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And we combine those posterior estimates in into a global estimate using some sort of consensus Monte Carlo.

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And we'd have weighted averages of the posterior M CMC chains.

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That's as I described.

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So then an alternative is to divide the users into ten equal groups with respect to the number of classifications that they did.

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This works very well in our case because what we end up with is about 10 shards.

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With about half a million classifications per shot.

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And so then we fit the shards in parallel and then we combine combine that using some stratified sampling approaches.

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And we found this kind of alternative to the usual divide and recombine works really well here.

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So the benefits and drawbacks of this distributed computing approach is that we have efficient computing.

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We avoid repetition of these tasks, that because we have this distributed setup, we are we have a wealth of tools to do this.

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Now we have privacy prevert preservation in some sense because the we have the distributed

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analysis and we can also increase inferential power by combining the datasets.

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We do have, on the other hand, the potential for data leaks.

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We have we can have possible biased and variable inferences if we use just the naive approaches.

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It's usually limited to point estimates.

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It's more difficult to get uncertainty estimates, although that's changing and we still have some issues about time, degeneracy.

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And we have to be careful of that degeneracy of the weights that we have on the partial likelihoods or the the local likelihoods on that.

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And there's a lot of work on avoiding or addressing those issues.

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So I'd like to come now to to the approach that we're investigating currently, which is around Federated Learning.

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So now this is the next step out. So this is really decentralised approach where we want to analyse the data without the data leaving the source.

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So this can then help us to avoid the ethical, legal, political, administrative and computational barriers to combining data from multiple sources.

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It increases control for the the the the owners of the data.

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There is a potential to improve data quality and timeliness because the data will be managed by the data owners.

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And we also have then increased inferential capability if we by bringing together small or dispersed datasets.

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So the way that the federated analysis works is that we have groups, we have the parties, the manager and the communication computational framework.

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We have then the components. So we want to petition our data. We have a model.

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We have a privacy mechanism and the communication architecture.

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How are we going to get all these actors to talk? To each other, and then we also have the modelling approaches and.

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And this is where we can really play a role here.

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And combined with the computer scientists and the information technology people in in making this federated approach.

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So modelling approaches range from date, new networks based decision trees, regressions, support vector machines and so on.

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You'll see the sort of the the the image of the federated analysis.

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And below that, I have a figure also of the type of datasets that we might have.

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So we might have data that split or petitioned horizontally.

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So each of the the nodes, the local data, not local nodes, has all of the data.

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So the whys and the Xs that are required for the analysis. It's just that they have subsets of that that whole dataset.

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The other option is that we have data that split vertically.

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So one nodes holds one of the Xs, another node holds another X and another one holds the Y.

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And then we want to bring all of these data together. So there's different ways that the data at a petition.

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Now, there's a lot of approaches for federated analysis. But this is really sort of just in the last few years.

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So there's some commentaries that are useful to to to get an overview of this.

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There's an idea of having a repository with data sharing agreements and these repositories of very common now.

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And there's a whole lot of work on developing these. But the question is then about doing the analysis once we have these repositories.

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We also have Bayesian networks as a way of being able to include data from different areas.

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And this is used, for example, in this sample for survival prediction.

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There's neural networks to a lot of work on your networks. And then sequential and hierarchical Bayesian models.

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For now, we're starting to get into the correlated data for time series data.

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And also for spatial data. And there's also some work on very nice work on communication, efficient approaches.

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I'll just talk about those briefly in a minute. So we have for the federated sharing of genomic data sets, we have these.

395
00:46:01,140 --> 00:46:05,810
An example of genetic status it's in this case is an example of this.

396
00:46:05,810 --> 00:46:10,650
Some is federated sharing of internal registry sense here.

397
00:46:10,650 --> 00:46:16,980
So this is really going to be controlled. Each group controls its own data.

398
00:46:16,980 --> 00:46:24,000
They can dynamically add or drop instances from the group and they can make agreements about the group.

399
00:46:24,000 --> 00:46:37,730
So there's quite a lot of sort of federated or autonomous, some autonomy in the way that these groups might engage with the overall registry.

400
00:46:37,730 --> 00:46:43,790
This example is from from Jordan and colleagues.

401
00:46:43,790 --> 00:46:49,190
This work started around two thousand and fifteen sixteen when the archive paper

402
00:46:49,190 --> 00:46:55,250
appeared and then was published in 2018 and there's been extensions of the work since.

403
00:46:55,250 --> 00:46:59,660
But basically here, the way that this works is again, a surrogate likelihood approach.

404
00:46:59,660 --> 00:47:09,200
So we start off by initialising. They did not. And then we're going to transmit that value to local machines.

405
00:47:09,200 --> 00:47:11,710
The current day it to the local machines.

406
00:47:11,710 --> 00:47:19,980
We're going to now create the local gradient of the likelihood at each of the machines and we're going to transmit that machine.

407
00:47:19,980 --> 00:47:22,760
MJ, we're going to transmit that to two machine.

408
00:47:22,760 --> 00:47:32,090
And one, we're going to calculate then a global gradient on machine and one, we're going to form in the surrogate function there.

409
00:47:32,090 --> 00:47:36,800
And then we're going to either do two one of two things.

410
00:47:36,800 --> 00:47:43,430
We either update the THETAS directly or we're going to then have some sort of one stop,

411
00:47:43,430 --> 00:47:47,810
one step quadratic approximation to get our new values of thetas.

412
00:47:47,810 --> 00:47:53,300
Then we will do the whole thing. We'll transmit those. That again will update the the gradients.

413
00:47:53,300 --> 00:48:00,230
We'll bring those gradients back in. We'll combine the gradients, compute this the the the likelihood and so on.

414
00:48:00,230 --> 00:48:08,000
So it's a very computationally efficient way of using a surrogate likelihoods through the gradient.

415
00:48:08,000 --> 00:48:11,600
So this Bayesian approaches to this, I won't go through it,

416
00:48:11,600 --> 00:48:17,720
but it's really a similar sort of thing where now we're not going to be transmitting the posterior drawers anymore,

417
00:48:17,720 --> 00:48:24,490
which is computationally intensive. We're going to be transmitting these some of these gradients.

418
00:48:24,490 --> 00:48:35,020
And then we can show then for logistic regression of images in this type of by Jordan et al that we can see from the plot here,

419
00:48:35,020 --> 00:48:42,260
that tag that this approach is really gives us a much better classis classification.

420
00:48:42,260 --> 00:48:55,510
Right. Compared to the usual approach. I'm going to skip this example other than to say this is a spatial modelling approach, which is very useful.

421
00:48:55,510 --> 00:49:01,360
And one of the key to the future approaches that actually takes into account

422
00:49:01,360 --> 00:49:06,560
this some strongly correlated data and spatial approach that we have here.

423
00:49:06,560 --> 00:49:11,770
Am I going full time? Crystal? Oh, yeah.

424
00:49:11,770 --> 00:49:18,730
If you could finish relatively soon, then we'll have time for another question because we've got a few in their chat show.

425
00:49:18,730 --> 00:49:26,740
So coming back to our Atlas of Cancer, then we can combine cancer data sets across each state and count countries.

426
00:49:26,740 --> 00:49:34,960
That's what we would like to do. And so we partnered with a group called with them, the Netherlands Cancer Agency.

427
00:49:34,960 --> 00:49:38,230
And so they've been doing some excellent work about this time last year.

428
00:49:38,230 --> 00:49:46,060
I was in the Netherlands to talk to them about this. And they've done some excellent work in the meantime, a collaboration called URO Care.

429
00:49:46,060 --> 00:49:50,800
So this is open source federated analysis, which really demonstrates that this can be done.

430
00:49:50,800 --> 00:49:58,610
So achieved. And so if any of you are interested in this, I would recommend checking this site out.

431
00:49:58,610 --> 00:50:07,510
That is the site and teach six, which is open source privacy prevert preserving federated learning infrastructure.

432
00:50:07,510 --> 00:50:14,320
And they've got some great examples of combining data from the Netherlands and Tyre and Taiwan,

433
00:50:14,320 --> 00:50:20,860
combining data from different agencies and then combining data from the Netherlands and Italy.

434
00:50:20,860 --> 00:50:25,990
And so different kinds of federated approaches. So there's a federated approach.

435
00:50:25,990 --> 00:50:34,570
And you can see on the the right of the screen an approach where it talks about how these individual nodes work.

436
00:50:34,570 --> 00:50:38,110
So if people are interested.

437
00:50:38,110 --> 00:50:48,880
So you can have a federated generalised linear model approach where you can you can calculate the MLA for BTR via phishers scoring.

438
00:50:48,880 --> 00:50:54,940
So what you do is you calculate the the individual terms at each of the nodes.

439
00:50:54,940 --> 00:50:59,740
You then aggregate them to the the the global node.

440
00:50:59,740 --> 00:51:06,250
You get a beta out of that. And then the beta goes back to individual nodes and so on.

441
00:51:06,250 --> 00:51:15,190
So we can get then the original version of your care was where you had each of the individual countries.

442
00:51:15,190 --> 00:51:19,920
They all provided information to a single source. And then you got your estimates.

443
00:51:19,920 --> 00:51:25,630
B, the federated version is that the data stay where they are then the sum.

444
00:51:25,630 --> 00:51:28,540
This approach works as I described before.

445
00:51:28,540 --> 00:51:36,100
So you get these individual values and then you get your estimates and you show the estimates are relatively the same.

446
00:51:36,100 --> 00:51:39,850
So for virtual reefed either then we've done a similar thing with them.

447
00:51:39,850 --> 00:51:44,320
Federated analysis here with Federated Matrix factorisation.

448
00:51:44,320 --> 00:51:49,330
So we've taken a fact Matrix factorisation approach that I showed before.

449
00:51:49,330 --> 00:51:56,020
And we've included an adaptive learning rate. And we've used to Capstick gradient descent as an approach here.

450
00:51:56,020 --> 00:52:04,960
And so we've we've effectively decomposed the stochastic gradient descent approach so that we can use it in these federated approach.

451
00:52:04,960 --> 00:52:10,330
So what we get is a dynamic method. It's some it's privacy protection.

452
00:52:10,330 --> 00:52:19,750
It has learning efficiency significantly reduces the training time and the and maintains high predictive accuracy in this.

453
00:52:19,750 --> 00:52:28,530
So I won't go through the details of this, but. But you're welcome to to talk to me afterwards or we'll see from the slides.

454
00:52:28,530 --> 00:52:34,270
We do show that that has some strong advantages in this federated approach.

455
00:52:34,270 --> 00:52:37,660
So in summary, then, our data are changing.

456
00:52:37,660 --> 00:52:46,180
We have size, privacy, provenance, quality, diversity issues, federated analysis and Federated Learning offers some solutions.

457
00:52:46,180 --> 00:52:48,190
But we do need statistical methods.

458
00:52:48,190 --> 00:52:56,590
And combining it with their implementation, we've shown talked about two case studies and then looked at a number of approaches.

459
00:52:56,590 --> 00:53:03,500
As I said, this is work in progress and I'll be very happy for any comments and suggestions and I'll hand it back to you.

460
00:53:03,500 --> 00:53:09,670
Christo, thank you. Thank you very much. Unfortunately, we can't give you around for us.

461
00:53:09,670 --> 00:53:17,950
But for the people who say thank you very much indeed. So we have some questions already in the chat.

462
00:53:17,950 --> 00:53:27,880
And so one of them is about what assumptions you've made when you're analysing cancer data about the surveillance.

463
00:53:27,880 --> 00:53:33,940
So what are you getting a fixed proportion of cases or do they vary across areas?

464
00:53:33,940 --> 00:53:37,270
And then there was a bit of a follow up from the same thing is how do you account for

465
00:53:37,270 --> 00:53:43,080
different data collection methods in the different datasets that you're bringing together?

466
00:53:43,080 --> 00:53:53,300
In the cancer data, we're fortunate in that this census basically said the cancer is a notifiable disease.

467
00:53:53,300 --> 00:53:59,600
And we have a count. We have registries now. The registries aren't perfect, but but they're very good.

468
00:53:59,600 --> 00:54:03,740
And so and so we take these data as given. You're right, though,

469
00:54:03,740 --> 00:54:13,310
in terms of bringing together data sets in this federated approach for that may be of different quality and also different representation.

470
00:54:13,310 --> 00:54:25,220
So those kinds of issues, you as statisticians, we have some good ways of being able to deal with them with data that we need.

471
00:54:25,220 --> 00:54:34,700
We have sampling approaches that we have some sort of uncertainty that we might associate with them with different kinds of issues around sampling.

472
00:54:34,700 --> 00:54:38,420
And so we can bring those to bear on this federated approach.

473
00:54:38,420 --> 00:54:43,010
And I think it's really important for us, the statisticians, to be part of this.

474
00:54:43,010 --> 00:54:51,860
This move to these sorts of more decentralised analysis approaches.

475
00:54:51,860 --> 00:55:02,420
And so also relating to fisheries learning and how things are moving, would you be able to do model checking or model learning in this context?

476
00:55:02,420 --> 00:55:07,950
How does that affect these approaches? Yeah.

477
00:55:07,950 --> 00:55:15,510
I think this is a good case. The same as just the whole model uncertainty in the in the distributed computing case.

478
00:55:15,510 --> 00:55:23,070
And so this people at Oxford who's who have been working in this area a lot,

479
00:55:23,070 --> 00:55:31,650
in some ways the I think the federated approach actually might help us to to understand more of that model robustness.

480
00:55:31,650 --> 00:55:34,830
So if you think about this and when we can actually think about like,

481
00:55:34,830 --> 00:55:41,030
what are they surrogate likelihoods so that when we create these surrogate likelihoods about the local likelihoods and,

482
00:55:41,030 --> 00:55:50,520
um, and perhaps we can learn more about how robust our model is if taking into account the assumptions about the different nodes.

483
00:55:50,520 --> 00:55:53,400
But then what's how likely what are our likelihoods telling it?

484
00:55:53,400 --> 00:56:01,530
It's almost like we have replicates of the experiment, if you want, depending on whether we have the vertical or the horizontal petitioning.

485
00:56:01,530 --> 00:56:09,410
But we do have an opportunity, I think, to learn more about our models, perhaps in this situation when we set up.

486
00:56:09,410 --> 00:56:21,750
OK. And then more of a political context question, which is what would achieving spatial equality mean in the context of a cancer atlas?

487
00:56:21,750 --> 00:56:29,530
So, in other words, is that the worst performing area is being raised to the level of the better performing areas.

488
00:56:29,530 --> 00:56:37,210
So, yeah, so. Well, that's what you would hope, is that that you would have it.

489
00:56:37,210 --> 00:56:44,840
And that's why we were looking at, for example, how many deaths might we avoid or other kinds of measures like that.

490
00:56:44,840 --> 00:56:51,260
How much morbidity would we avoid if we were able to resolve that spatial inequality?

491
00:56:51,260 --> 00:56:57,710
So typically, even in a hospital situation, you might say what we would like to do is to get to the 80 percent mark.

492
00:56:57,710 --> 00:57:02,460
So we would like everybody to be at least at that 80 percent mark.

493
00:57:02,460 --> 00:57:06,400
You know, it's one of those. I look forward to the day when everybody earns above the average wage.

494
00:57:06,400 --> 00:57:11,970
But that's pretty much what we're trying to aim for here. OK.

495
00:57:11,970 --> 00:57:16,470
And then there was a more technical question, which was about a specific parameter.

496
00:57:16,470 --> 00:57:27,030
What is the impact of the choice of kasib you? For instance, why is this taking today the power of a fourth?

497
00:57:27,030 --> 00:57:33,630
Yes, sir, the the the power of the fourth was because of the distance metric that we used.

498
00:57:33,630 --> 00:57:37,920
And I'm happy to go through the details, so we'll talk about that.

499
00:57:37,920 --> 00:57:44,970
And that distance metric then was the way that we created these some of these shots.

500
00:57:44,970 --> 00:57:51,230
And then the case up, you was actually being developed on each of the shots.

501
00:57:51,230 --> 00:57:59,820
So the perimeter that was really inducing the sparsity of those those vectors was really the gamma.

502
00:57:59,820 --> 00:58:10,900
That was it was in both the U and the V variant, the variances for both the U and the V turns.

503
00:58:10,900 --> 00:58:18,630
Thanks. And then I have a question about the the people that you've got sort of evaluating your images.

504
00:58:18,630 --> 00:58:25,050
And so when you're recruiting nonexperts to do that, is it possible to somehow.

505
00:58:25,050 --> 00:58:29,040
I mean, if you have only a limited number for each person, it probably doesn't matter so much.

506
00:58:29,040 --> 00:58:37,700
But if you were going forward with people over a longer time, is it possible to provide feedback to help improve the performance of individuals?

507
00:58:37,700 --> 00:58:43,020
So then. I mean, I suppose you could smooth everybody in the same direction, which wouldn't necessarily help.

508
00:58:43,020 --> 00:58:50,780
But I just wondered whether or not it you can have a sort of feedback to improve performance.

509
00:58:50,780 --> 00:59:01,100
Yes, definitely so this. This couple of things fun, is this a learning parameter in that in that equation that we have the three plus model?

510
00:59:01,100 --> 00:59:05,540
And so we can we people will learn as they go along as well.

511
00:59:05,540 --> 00:59:07,850
But if we can certainly have feedback, in fact,

512
00:59:07,850 --> 00:59:18,290
what we're doing at the moment is creating an AR to VR package so people can actually then use we then create virtual reality and then annotate.

513
00:59:18,290 --> 00:59:30,860
So I have eyes like artificial intelligence so we can have questions and and reminders and training actually appear in the virtual reality world.

514
00:59:30,860 --> 00:59:37,040
It's pretty exciting moment, but that's a topic for another time.

515
00:59:37,040 --> 00:59:43,400
OK. So what are the feet where the bits of feedback we got was what an inspiring talk.

516
00:59:43,400 --> 00:59:49,500
This has been to to finish the week with which is perhaps a bit premature for many of our weeks.

517
00:59:49,500 --> 00:59:55,250
It depends on where you are, how close you are to the end of your week. But it's been great to hear from you.

518
00:59:55,250 --> 01:00:03,350
It's pretty interesting to to have such specific examples that are both important and and also very different.

519
01:00:03,350 --> 01:00:06,890
So you can see how it's being used in a number of contexts.

520
01:00:06,890 --> 01:00:13,340
And that, I think, really helps us envision, you know, the wide range of other opportunities where this can be brought together.

521
01:00:13,340 --> 01:00:19,400
We're also in a particular context within the U.K. of just having gone through Brexit.

522
01:00:19,400 --> 01:00:24,590
And so that does change some of our data sharing relationships with other countries.

523
01:00:24,590 --> 01:00:29,930
And so it would be important for us to think about these federated approaches and how this might be

524
01:00:29,930 --> 01:00:38,720
used to avoid running into complications with data sharing and where different datasets are stored,

525
01:00:38,720 --> 01:00:45,770
that we can still get the benefits of all the data that are out there without having to put them all in the same place.

526
01:00:45,770 --> 01:00:52,510
Yeah, that's true. I think it will be it's a challenge that all of us are going to need to face into work.

527
01:00:52,510 --> 01:01:03,780
Right. We can certainly learn from each other. Well, thank you very much again for spending part of your evening with us.

528
01:01:03,780 --> 01:01:05,700
Thank you very much for the opportunity.

529
01:01:05,700 --> 01:01:13,500
It's a great honour to be able to speak and and especially for such a great time, for such a great cause and a great memory.

530
01:01:13,500 --> 01:01:23,970
So it's fantastic that you win. You remember people in this way, and I'm proud and pleased to be part of it.

531
01:01:23,970 --> 01:01:27,750
Thank you. Thank you very much. And we we still owe you a dinner.

532
01:01:27,750 --> 01:01:33,280
So at some point in the future, you don't really speak again if you're in the Oxford area.

533
01:01:33,280 --> 01:01:38,550
Oh, OK. It's a deal. Thank you. In a more traditional manner.

534
01:01:38,550 --> 01:01:47,663
Okay. Thanks very much, Crystal. And thank you very much, everybody, for attending today.